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Updated: Jul 14, 2025

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Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
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双極性障害 の 診断 と 治療: 概要
Andrew A Nierenberg1,2, Bruno Agustini3, Ole Köhler-Forsberg1,4,5,6
1Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital, Boston.
JAMA
|October 10, 2023
まとめ
双極性障害は 世界中で何百万人もの人に 影響を及ぼし 気分の変化を伴い 診断が遅れていることが多い 早期の介入と一貫した治療は,より良い結果と死亡リスクの減少に不可欠です.
科学分野:
- 精神医学 と 神経科学
- 臨床心理学
- 公衆衛生
背景:
- 双極性障害は800万人の米国人,そして世界中で4000万人に影響し,再発性うつ病および躁うつ病/躁うつ病のエピソードが特徴です.
- 症状の発症は典型的には15歳から25歳の間に起こり,うつ病は最も頻繁な初期症状であり,うつ病症状は症状の75%を占める.
- 初期うつ病エピソードから平均9年後の遅れた診断は一般的であり,予後に大きな影響を与える.
結論:
- 双極性障害は,有意に寿命が短縮され (12-14歳) 心血管疾患による死亡率が増加します.
- メタボリックシンドローム,肥満,喫煙,2型糖尿病の 高い流行は 早期死亡に寄与する.
- 年間自殺率はかなり高い (0.9%対0.014%),双極性障害を持つ人の15〜20%が自殺する.
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