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Updated: Jul 13, 2025

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

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大量バイスピケットフェンスポルフィリンを用いたヘム-HNOモデル複合体の安定化とNOによる反応性研究

Elizabeth C Manickas1, Ashley B LaLonde1, Michael Y Hu2

  • 1Department of Chemistry and Department of Biophysics, The University of Michigan, Ann Arbor, Michigan 48109-1055, United States.

Journal of the American Chemical Society
|October 12, 2023
PubMed
まとめ

研究者は安定したヘム-ニトロキシル (HNO) モデル複合体を作成し,最初の振動特性を提供し,シトクロームP450norによって窒素酸化物 (NO) をN2Oに還元する役割を示した.

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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