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関連する概念動画

Tumor Immunotherapy01:27

Tumor Immunotherapy

539
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
539
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

951
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
951
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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関連する実験動画

Updated: Jul 13, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

300

技術 的 に 設計 さ れ た バクテリア は T 細胞 を 腫瘍 に 誘導 する

Eric M Bressler1, Wilson W Wong1

  • 1Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, USA.

Science (New York, N.Y.)
|October 12, 2023
PubMed
まとめ

エンジニアリングされたT細胞とバクテリアは 腫瘍細胞を標的にし 排除するために協力し 癌の免疫療法に 新たなアプローチを 提供します

科学分野:

  • 免疫学
  • 微生物学
  • 腫瘍学

背景:

  • 腫瘍細胞は 免疫の検出を回避する
  • 現在のがん治療には 限界があります

研究 の 目的:

  • T細胞とバクテリアを合成して 腫瘍細胞を破壊します

主な方法:

  • T細胞の遺伝子組み換え
  • 腫瘍を標的にする 細菌工学

主要な成果:

  • 腫瘍部位に T細胞とバクテリアの共同局所化が示されました
  • 腫瘍細胞の有意な殺戮を in vitro と in vivo で観察した.

結論:

  • このT細胞による細菌系は 癌の治療に有望です
  • 臨床応用についてはさらなる研究が必要である.

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Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Last Updated: Jul 13, 2025

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Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
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