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Updated: Jul 12, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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リソーム標的化キメラによる標的膜タンパク質分解の細胞決定因子の解明

Green Ahn1,2, Nicholas M Riley1,2, Roarke A Kamber3

  • 1Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|October 19, 2023
PubMed
まとめ

レトロマー遺伝子を破壊すると,リソソーム標的化キメラ (LYTAC) の膜タンパク質の分解が強化され,LYTACのリサイクルが制限される. 治療開発のためのLYTACの有効性をさらに最適化します.

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