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Updated: Jul 12, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

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MDM2 HIFシグナリングの調節が,高縮性心筋病における微血管機能障害を引き起こす

Puneeth Shridhar1,2, Michael S Glennon1, Soumojit Pal1

  • 1Division of Cardiology, Department of Medicine, and Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute (P.S., M.S.G., S.P., C.J.W., E.J.C., P.B., N.C.G., D.B., J.R.B.), University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA.

Circulation
|October 27, 2023
PubMed
まとめ

ハイパートロフィック心筋病 (HCM) の微小血管機能障害は,心臓の拡大に先立つ毛細血管の成長障害から生じる. MDM2 (ネズミのダブル分2) タンパク質をターゲットにすることで,HCMマウスモデルにおける機能障害を予防します.

キーワード:
毛細血管心筋病 縮症低酸素筋動脈ミオシン重鎖プロテアソーム・エンドペプチダゼ複合体サルコメア

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