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関連する概念動画

Menopause01:28

Menopause

175
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
175
Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

408
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
408
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

538
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
538
Signs of Puberty01:27

Signs of Puberty

375
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
375
Ovarian Cycle01:27

Ovarian Cycle

1.3K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
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関連する実験動画

Updated: Jul 12, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
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Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

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哺乳類には更年期があるの?

Ivana Winkler1, Angela Goncalves1

  • 1German Cancer Research Center (DKFZ), Somatic Evolution and Early Detection, 69120 Heidelberg, Germany.

Cell
|October 27, 2023
PubMed
まとめ
この要約は機械生成です。

排卵が永久に停止する 閉経はヒトだけでなく 哺乳類にも共通しています この研究では 更年期が再定義され 動物の生殖的老化を よりよく比較し 理解できるようになりました

さらに関連する動画

Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification
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関連する実験動画

Last Updated: Jul 12, 2025

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

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Performing Vaginal Lavage, Crystal Violet Staining, and Vaginal Cytological Evaluation for Mouse Estrous Cycle Staging Identification
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Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
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科学分野:

  • 生殖生物学
  • 比較内分泌学
  • 哺乳類の繁殖

背景:

  • 非人間哺乳類における更年期に関する理解は,意味論的な問題とデータ不足によって制限されています.
  • 過去の月経出血に基づく 更年期の伝統的な定義は,種間比較には不十分です.
  • 多種多様な哺乳類の生殖老化を研究するには,明確で普遍的に適用可能な定義が必要です.

研究 の 目的:

  • 哺乳類の種間比較を容易にするように 更年期を再定義する.
  • 異なる哺乳類のオーダーにおける 更年期の流行を調査する.
  • 生殖老化の研究とその進化的含意を進める.

主な方法:

  • 哺乳類の生殖サイクルに関する既存のデータの文献レビューと合成.
  • 排卵の停止を特定するための様々な哺乳類の繁殖パターンの分析
  • 絶え間ない排卵に基づいた更年期の定義の改正.

主要な成果:

  • 閉経は,排卵が永久に停止すると定義され,人間に特有のものではありません.
  • 証拠によると 更年期は多くの哺乳類に 広く存在しています
  • 改訂された定義は,動物界における生殖的老化をより広く理解することを可能にします.

結論:

  • 排卵の永久停止は比較研究における更年期のより正確で包括的な定義です.
  • 閉経は様々な哺乳類の 生殖戦略です
  • この再定義は 更年期の進化と生態学的影響の研究に 新たな道を開きます