急性心臓死亡の頻度における循環時変動

J E Muller, P L Ludmer, S N Willich

Circulation

|January 1, 1987

まとめ

心臓発作による突然死は,毎日のリズムを示し,朝の時間にピークに達します. 心臓のイベントにおけるこの昼夜パターンは,予防戦略の洞察を提供することができる.

科学分野:

心臓病学心臓病学
クロノバイオロジークロノバイオロジー
公衆衛生は公衆衛生である.

背景:

心臓発作による突然死 (SCD) は,死亡率の重要な原因である.
非致死性心筋梗塞 (MI) は,昼夜リズムを示しています.
SCDの時間的なパターンを理解することは,公衆衛生にとって極めて重要です.

研究の目的:

急性心臓死 (SCD) が昼夜リズムを示すかどうかを調査する.
SCDの時間パターンを非致死性心筋梗塞 (MI) と比較する.

主な方法:

マサチューセッツ州で1983年に病院外での急性心臓発作による死亡者2203人の死亡証明書の分析.
各 SCD イベントの発生日時を検証する.

主要な成果:

急性心臓死 (SCD) は,顕著な昼夜変動を示した.
発症率は夜中に最も低く,午前7時から11時までの間にピークに達しました.
このパターンは,非致死性心筋梗塞と心筋梗塞不全のパターンに非常に似ています.

結論:

急性心臓死 (SCD) は,重要な昼夜リズムを示し,朝の発生率が増加します.
この発見は,SCDを午前イシュケミアまたはプライマリーリズム障害に結びつける仮説を裏付けている.
朝の生理学的変化に関するさらなる研究は,SCDのメカニズムと予防を明らかにすることができます.

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