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Updated: Jul 11, 2025

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity
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Published on: January 5, 2016

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フォーマルデヒドはS-アデノシルメチオニンの生物合成と単炭素代謝を調節する

Vanha N Pham1, Kevin J Bruemmer1, Joel D W Toh1

  • 1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|November 2, 2023
PubMed
まとめ

フォーマルデヒド (FA) は,MAT1Aを標的にしてS-アデノシルメチオニン (SAM) の生成を阻害し,一炭素代謝と表遺伝子調節に影響を与えます. この研究では,細胞がFAによって引き起こされたSAMの減少を補償するフィードバックループが明らかになりました.

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