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Updated: Jul 11, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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シクロパミンの非対称合成,ヘッジホッグ (Hh) 信号経路阻害剤

Hao Shao1, Wenheng Liu2, Muhan Liu3

  • 1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

Journal of the American Chemical Society
|November 10, 2023
PubMed
まとめ

研究者は新しい2段階のリレー戦略を使用して,ヘッジホッグ (Hh) 信号経路を阻害するステロイドアルカロイドであるサイクロパミンを合成しました. この進歩は,Hhシグナリングをターゲットにすることで,新しいがん治療薬を開発する可能性を秘めています.

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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