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Updated: Jul 11, 2025

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
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NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Published on: June 4, 2021

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600MHzのNMRスペクトロメータで5分間の取得で混合物中の亜微細分分析物質の検出

Congcong Zhang1, Li Xu1, Qingxia Huang1

  • 1State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Metabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular Phenomics, Zhongshan Hospital, Fudan University, Shanghai 200438, China.

Journal of the American Chemical Society
|November 13, 2023
PubMed
まとめ

新しい核磁気共鳴 (NMR) 方法は,アミノ化合物の感度を高め,低濃度での検出を可能にします. この迅速な技術により,様々な科学分野における複雑な混合物の定量分析が改善されます.

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The position of the absorption signal of a sample is reported relative to the position of the signal of tetramethylsilane (TMS), which is added as an internal reference while recording spectra. The difference between the absorption frequencies of the sample and TMS (in Hz) is divided by the spectrometer operating frequency (in MHz) to obtain a dimensionless quantity called the chemical shift. It is reported on the δ (delta) scale and expressed in parts per million.
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