関連する実験動画

Updated: Jul 11, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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TAAR1の構造とシグナリングメカニズムは,好ましいアゴニスト設計を可能にしました

Pan Shang1, Naikang Rong1, Jing-Jing Jiang2

  • 1NHC Key Laboratory of Otorhinolaryngology, Qilu hospital and School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China; Advanced Medical Research Institute and Meili Lake Translational Research Park, Shandong University, Jinan, Shandong 250012, China.

Cell
|November 14, 2023
PubMed
まとめ

内生代謝産物および薬物によるトレースアミン関連受容体1 (TAAR1) の活性化は,統合失調症の治療における構造的洞察を示している. 特定のポケットをターゲットにすることで 信号伝達が調節され 伝統的なG経路を超えて 新しい治療法が提供されます

キーワード:
GPCR についてTAAR1 についてクリオ・エム構造統合失調症トレースアミン関連受容体

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