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Updated: Jul 11, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

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分子間激素結合とPd触媒サイクリングによって可能になったタクソルの総合成

Takahiro Watanabe1, Kyohei Oga1, Hiroaki Matoba1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo113-0033, Japan.

Journal of the American Chemical Society
|November 16, 2023
PubMed
まとめ

研究者らは,複合的な抗腫瘍性ディテルペノイドであるTaxol (1) の完全な合成を達成した. この28段階の合成は,複雑な四環構造の効率的な構築のために,新しい断片設計とラジカルカップリングを使用しました.

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