Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

The Physiology of Taste01:24

The Physiology of Taste

3.9K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.9K
Gustation01:43

Gustation

48.1K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
48.1K
Taste Buds and Receptors01:20

Taste Buds and Receptors

2.1K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.1K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.5K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.5K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

4.6K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
4.6K
Neural Regulation01:37

Neural Regulation

39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Deep Cellular and Spatial Profiling of the Mouse Spinal Cord Reveals Sex-Specific Neuron Types and the Ascending Projection Neuron Repertoire.

bioRxiv : the preprint server for biology·2026
Same author

Projections from subfornical organ to infralimbic cortex modulate carbon dioxide associated fear.

bioRxiv : the preprint server for biology·2026
Same author

A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction.

Journal of neuroinflammation·2026
Same author

Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice.

PloS one·2026
Same author

A consensus spinal cord cell type atlas across mouse, macaque, and human.

bioRxiv : the preprint server for biology·2026
Same author

A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction.

Research square·2026

関連する実験動画

Updated: Jul 10, 2025

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
07:40

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds

Published on: February 11, 2021

3.5K

パラレルな神経経路は,ナトリウム消費と味覚を制御する.

Yameng Zhang1, Allan-Hermann Pool2, Tongtong Wang1

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Cell
|November 21, 2023
PubMed
まとめ

脳はナトリウム濃度に基づいて 塩の好みを切り替えます 後頭脳と前頭脳における 異なる神経回路 制御塩

キーワード:
食欲ホメオスタティック神経回路内部状態プロスタグランジン塩の魅力塩への嫌悪感覚変調ナトリウムホメオスタシス味覚について

さらに関連する動画

New Methods to Study Gustatory Coding
10:59

New Methods to Study Gustatory Coding

Published on: June 29, 2017

9.4K
In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila
06:30

In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila

Published on: March 7, 2025

525

関連する実験動画

Last Updated: Jul 10, 2025

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
07:40

Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds

Published on: February 11, 2021

3.5K
New Methods to Study Gustatory Coding
10:59

New Methods to Study Gustatory Coding

Published on: June 29, 2017

9.4K
In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila
06:30

In Vivo Calcium Imaging of Taste-Induced Neural Responses in Adult Drosophila

Published on: March 7, 2025

525

科学分野:

  • 神経科学
  • 味覚 味覚
  • ホメオスタシス

背景:

  • 塩の享楽的価値は 内部状態によって変化し 飽きたときの嫌悪からナトリウムが不足したときに食欲へと変化します
  • この状態に依存する塩のバレンスのスイッチの背後にある神経機構はよく理解されていません.

研究 の 目的:

  • 塩のバランスを制御する神経回路の解明です
  • 塩の味覚と耐性に関与する特定の細胞タイプと分子経路を特定する

主な方法:

  • 状態から細胞タイプへのマッピングのためのトランスクリプトミクス.
  • 哺乳類のモデルにおける 神経操作
  • 電気生理学的記録で 味覚を評価する

主要な成果:

  • 後頭脳と前頭脳 (lamina terminalis, LT) の異なる神経回路が塩の価値を制御する.
  • プロスタグランジンE2受容体 (Ptger3) を発現する特定の種類のLTニューロンは,塩分耐性をコードする.
  • これらのLTニューロンは,プロスタグランジンE2-Ptger3軸を通して嫌味感を調節する.

結論:

  • 塩の好みは,異なる食欲 (後脳) と耐性 (前脳) の信号によって双方向的に調節されます.
  • このバイモダル調節は 体の内部状態に基づいてナトリウム消費を決定します
  • 塩味嫌悪を調節するプロスタグランジンE2-Ptger3経路の新たな役割が特定されました.