細胞に浸透するペプチドが孔形成ペプチドとどのように異なるか:誘導されたトランスメブラン孔の構造と安定性

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Updated: Jul 10, 2025

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
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Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

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Haleh Alimohamadi1,2,3,4, Jaime de Anda1,2,3,4, Michelle W Lee1

  • 1Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90025, United States.

Journal of the American Chemical Society
|November 21, 2023
PubMed
まとめ

研究者は,立方相幾何学を用いてトランスメブラン毛穴の大きさを推定する新しい方法を開発しました. このアプローチは,抗菌性ペプチド (AMP) や細胞浸透性ペプチド (CPP) のようなペプチドが,脂質膜に穴を開く仕組みを理解するのに役立ちます.

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