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Updated: Jul 10, 2025

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
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炎症性カスパース-4によるサイトカイン分裂に関する構造的洞察

Pascal Devant1, Ying Dong2,3, Julian Mintseris4

  • 1Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Nature
|November 22, 2023
PubMed
まとめ

人間のカスパース-4は,炎症体とカスパース-1をバイパスしてインタールイキン-18 (IL-18) を割ります. Cryo-EMは,ガスダーミンDとは異なるカスパース-4サイトカイン処理と基板捕獲の構造的メカニズムを明らかにします.これは先天的な免疫研究に影響します.

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