荒れ果てた けれど 簡単に 航行 できる 健身 場
Andrei Papkou1, Lucia Garcia-Pastor2, José Antonio Escudero2
1Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Science (New York, N.Y.)
|November 23, 2023
まとめ
荒れ果てたフィットネスの風景は 複雑ですが ダーウィンの進化を阻害していません 豊富な経路によって フィットネスのピークに到達できますが 偶然の出来事により 進化の成果は予測不可能になります
科学分野:
- 進化生物学
- ゲノミクス
- 生物化学
背景:
- フィットネス・ランドスケープ理論では 複雑な進化の経路が適応を妨げると考えられています
- この理論の実験的検証は,特に複雑な生物学的システムでは,限られている.
研究 の 目的:
- 重要な酵素の高解像度フィットネス・ランドスケープを実験的にマッピングする.
- 適応進化のダイナミクスに 景観の荒れが与える影響を調査する.
主な方法:
- ゲノム編集を活用して 26万種類以上の遺伝子を生成し 適合性を評価しました
- ディヒドロフォラート還元酵素とその抗生物質トリメトプリムとの相互作用に焦点を当てた
主要な成果:
- フィットネスの景色は非常に荒れ果てたことが判明し,514の明確なフィットネスピークが特徴でした.
- 荒れ果てたところにも関わらず,最も高いフィットネスピークにたどり着くための道は豊富にありました.
- 進化の軌道はストカスティックな要因に大きく依存していることを示している.
結論:
- 酵素の進化は荒れ果てた地形でも可能で 高いフィットネス状態への多くの経路がある
- 景観の荒れは必ずしも進化を阻害するわけではないが,その予測可能性を著しく低下させる.
- 生物学的システムにおける最適化の複雑さは,現在のモデルの再評価を必要とします.
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