イギリスのバイオバンクにおける加速計で測定された身体活動,ステップ数,およびがんリスクの用量反応:前向きなコホート分析
Alaina H Shreves1, Scott R Small2, Ruth C Travis3
1Nuffield Department of Population Health, University of Oxford, Oxford, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lancet (London, England)
|November 24, 2023
まとめ
高度な身体活動と毎日の歩数増加は,成人における癌リスクの減少と関連しています. 運動量を増やすことは 低強度であっても 癌のリスクを下げるための 実践的な公衆衛生戦略かもしれません
科学分野:
- 流行病学について
- 公衆衛生
- ゲロントロジー
背景:
- 癌は老化と密接に関連しています
- 身体活動などの 変更可能なライフスタイルは 癌のリスクに影響を及ぼします
- 高齢者におけるステップ数とがんリスクの関係については,さらなる調査が必要である.
研究 の 目的:
- アクセレロメーターで測定した全身活動,ステップ数,がんリスクとの関連を調査する.
- 異なる身体活動強度間の時間の再分配が癌のリスクに与える影響を調査する.
- 身体活動指標と癌のリスクとの投与反応関連性を評価する.
主な方法:
- イギリスのバイオバンクデータを用いた前向きなコホート研究 (n=86,556).
- アクセレロメーターデータ (Axivity AX3) は,総活動とステップ数を測定するために7日間収集されました.
- 複数の共変数で調整された13種類の癌の複合エンドポイントの危険性比を計算するために使用されたコックス比例危険性モデル.
主要な成果:
- 身体活動による癌のリスクが低かった (HR per 1 SD: 0. 85)
- 毎日30分を中等から激しい運動に,または1時間を軽い運動に割り当てることは,癌のリスクの減少と関連していました.
- 1日1万歩を踏み出すと,5000歩と比べると,がんのリスクが著しく低下しました (HR: 0.81).
結論:
- 身体活動の総量と毎日の歩数増加は,身体活動に関連した癌のリスクの減少と関連しています.
- 身体活動に時間を割くことは 濃度に関係なく がん予防に有益であるようです
- 低強度な運動を増やし 日々の歩数を増やすことは 高齢者向けに効果的な公衆衛生対策として役立つでしょう
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