関連する実験動画

Updated: Jul 9, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
08:23

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

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ユカリオットリボソーム転位中のmRNA読み取りフレームの維持

Nemanja Milicevic1, Lasse Jenner1, Alexander Myasnikov2

  • 1Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR7104, INSERM U1258, University of Strasbourg, Strasbourg, France.

Nature
|November 29, 2023
PubMed
まとめ

タンパク質合成は,真核生物における延長因子2 (eEF2) によって促進される正確なmRNAとtRNAの動きに依存する. この研究は,eEF2とリボソーム構造が 翻訳の正確性を確保し,エラーを防止する方法を示しています.

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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