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Updated: Jul 9, 2025

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
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Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution

Published on: July 8, 2019

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mRNAのN1-メチルプセウドウリデリレーションは,1のリボソームフレームシフトを引き起こす

Thomas E Mulroney1, Tuija Pöyry1, Juan Carlos Yam-Puc1

  • 1MRC Toxicology Unit, University of Cambridge, Cambridge, UK.

Nature
|December 6, 2023
PubMed
まとめ

SARS-CoV-2 のように改変されたmRNAワクチンは,N1-メチルプセウドウリジンによるリボソームのフレームシフトを引き起こす可能性があります. 配列の最適化はこれらの意図しないタンパク質を減らすことができます.

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