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Updated: May 7, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

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トレリスツリーベースの分析は,患者によるオーガノイド薬反応のストロマル調節を明らかにする

María Ramos Zapatero1, Alexander Tong2, James W Opzoomer1

  • 1Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London WC1E 6DD, UK.

Cell
|December 8, 2023
PubMed
まとめ

大量サイトメトリのプラットフォームと分析方法を開発し,大腸がん (CRC) のオーガノイドとその微小環境を研究しました. これは,がんに関連した線維芽細胞 (CAF) が幹細胞の状態を変えることで,CRC細胞を化学療法から保護する方法を示しています.

キーワード:
CAF について保護された産地名PTMシグナリングトレリス癌に関連する線維芽細胞化学抵抗性マスサイトメトリー患者からのオーガノイドプラスティシティscRNA-seq について単細胞スクリーニング

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