関連する実験動画

Updated: Jul 9, 2025

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

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分子図鑑は,散発的な結腸直腸腫瘍における進化的および微環境的動態を明らかにする

Cody N Heiser1, Alan J Simmons2, Frank Revetta3

  • 1Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Cell
|December 8, 2023
PubMed
まとめ

この研究では,空間的なマルチオミクスを使用して結腸直腸がんの進化をマッピングし,腫瘍の進行経路と微小環境の変化を明らかにしています. 新しい免疫排除シグネチャー (IEX) は,患者の結果と治療反応を予測します.

キーワード:
大腸がん免疫の排除マイクロ衛星の不安定性マルチプレックスイメージング変異空間トランスクリプトミクス幹細胞腫瘍の進化腫瘍の進行

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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment06:05

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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