毒性ショック症候群. インフルエンザとインフルエンザに似た疾患の新たに認められた合併症である
JAMA
|February 27, 1987
まとめ
重度の低血圧と死亡,毒性ショック症候群 (TSS) と一致する,合併症性インフルエンザの発生. 患者にはStaphylococcus aureusが特定され,一部はTSS毒素-1を産生し,インフルエンザとTSSとの関連性を強調した.
科学分野:
- 感染症 感染症は感染症です.
- 毒理学 毒理学 毒理学
- エピデミオロジー エピデミオロジー
背景:
- インフルエンザやインフルエンザに似た疾患は,深刻な合併症を引き起こす可能性があります.
- 毒性ショック症候群 (Toxic Shock Syndrome,TSS) は,典型的には,黄金球菌 (Staphylococcus aureus) 感染症に関連した重症な状態である.
研究 の 目的:
- インフルエンザの流行中に重度の低血圧または死亡の症例を調査するために.
- インフルエンザと毒性ショック症候群 (TSS) の間の潜在的な関連性を決定する.
主な方法:
- ミネソタ州でのインフルエンザの流行中に重症になった9人の症例の遡及的レビュー.
- Staphylococcus aureusの細菌培養と毒素分析について.
- 既定の基準に基づいてインフルエンザとTSSの診断確認.
主要な成果:
- インフルエンザまたはインフルエンザに似た疾患に関連したTSSの9例が特定され,5例が死亡しました.
- Staphylococcus aureusは8人の患者から隔離され,毒素の産生 (TSST-1または腸毒素B) は7つの単離物で確認されました.
- インフルエンザB感染は3人の患者で確認され,TSSは9人の患者全員で確認されたか,可能性が高い.
結論:
- 毒性ショック症候群 (TSS) は,インフルエンザやインフルエンザに似た疾患の深刻な合併症である可能性があります.
- この発見は,インフルエンザの季節に重度の病気を患っている患者のTSSを検討することの重要性を強調しています.
- Staphylococcus aureus,特に毒素を生成する菌株は,TSSの発症に重要な役割を果たしています.
関連する概念動画
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Inhalation Anthrax
Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive, spore-forming bacterium. It primarily affects herbivorous animals but can be transmitted to humans through skin contact, ingestion, or inhalation of spores.Cutaneous anthrax, the most common form, typically results from direct contact with bacterial spores through skin abrasions and is generally less severe. Gastrointestinal anthrax results from eating undercooked or contaminated meat. It affects the mouth, throat, or...
Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Influenza
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...


