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Updated: Jul 8, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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活性化されていないアルケンのNi-カタライズされた1,1-および1,3-アミノボレーション

Mao-Yun Lyu1, Gabriel N Morais2, Shuming Chen2

  • 1Department of Chemistry, Indiana University, 800 E. Kirkwood Ave, Bloomington, Indiana 47405, United States.

Journal of the American Chemical Society
|December 11, 2023
PubMed
まとめ

新しいニッケル触媒反応は,アルケンの1,1および1,3ボリラミネーションを達成する. この突破は,これまで報告されていないボリラミネーション経路を可能にすることで,合成化学のツールを拡張します.

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Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation

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In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
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