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Updated: Sep 24, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

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Published on: September 21, 2011

転写強化の構成活性化剤であるグルココルチコイド受容体の変異体

P J Godowski, S Rusconi, R Miesfeld

    Nature
    |January 22, 1987
    PubMed
    まとめ

    グルココルチコイド受容体はDNAと結合し,遺伝子発現を活性化します. 新種の受容体変異体は,この機能が構成的であることを示し,ホルモン結合が既存のDNA結合および強化ドメインを明らかにすることを示唆しています.

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