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Updated: Jul 7, 2025

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ラブ29に依存するレシピキナーゼ2の非対称活性化

Hanwen Zhu1, Francesca Tonelli2,3, Martin Turk4

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Science (New York, N.Y.)
|December 21, 2023
PubMed
まとめ

レウシンに富んだリピートキナーゼ2 (LRRK2) の機能獲得変異がパーキンソン病を引き起こす. 新しい構造は,Rab29がLRRK2を活性化する方法を示し,パーキンソン病の治療のためにLRRK2阻害剤を開発するための洞察を提供します.

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