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Updated: Jul 7, 2025

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
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Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

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行動中の転写開始の構造的視覚化

Xizi Chen1,2, Weida Liu1, Qianmin Wang1

  • 1Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.

Science (New York, N.Y.)
|December 21, 2023
PubMed
まとめ

この研究は,RNAポリメラーゼIIによる転写開始のダイナミックなプロセスを明らかにしています. 一般転写因子 (GTF) が早期のRNA合成に不可欠であるが,プロモーター脱出のために解離しなければならないことを示している.

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