関連する実験動画

Updated: Jul 7, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
06:17

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

532

構成的にダイナミックなヘリカーゼメカノ酵素のアロステリック共性阻害剤を開発するための機能ファースト"スカウトフラグメント"ベースのアプローチ

Jared R Ramsey1,2, Patrick M M Shelton2, Tyler K Heiss2

  • 1Tri-Institutional PhD Program in Chemical Biology, New York, New York 10021, United States.

Journal of the American Chemical Society
|December 22, 2023
PubMed
まとめ

研究者は,DNA/RNAプロセスと病気において重要な酵素であるヘリケアスの共性阻害剤を作成するために,電化スカウト断片を使用して新しいアプローチを開発しました. この方法はウイルスとヒトのヘリケアスを成功裏に標的とし,新しい治療戦略を提供しました.

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