関連する実験動画

Updated: Jul 6, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

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TCF4に依存する遺伝子調節ネットワークは,メラノーマの免疫療法に対する耐性を授与する

Joanna Pozniak1, Dennis Pedri2, Ewout Landeloos3

  • 1Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium.

Cell
|January 5, 2024
PubMed
まとめ

メラノーマ細胞は,免疫反応を抑制することで,免疫チェックポイントブロック (ICB) に抵抗します. TCF4調節器を標的とした治療は,腫瘍の免疫性およびICBおよび標的治療に対する感受性を高めます.

キーワード:
BET阻害EMT についてTCF4 について抗原の表示チェックポイント免疫療法脱差する腫瘍内異質性メラノーマ単細胞トランスクリプトミクス腫瘍の微小環境

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