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Updated: Jul 5, 2025

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TetRにおけるホットスポット変異による多重メカニズムによるAllosteryの調節

Jiahua Deng1, Yuchen Yuan1, Qiang Cui1,2,3

  • 1Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

Journal of the American Chemical Society
|January 17, 2024
PubMed
まとめ

テトラサイクリン抑制剤 (TetR) などのタンパク質におけるアロステリックホットスポット変異の予測は,生物医学的な応用において極めて重要です. 分子ダイナミクスシミュレーションで これらの変異を評価し 治療や工学的な取り組みを導くことができます

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