非正規の皮質-桃体経路による上から下の飛行制御
Chandrashekhar D Borkar1,2, Claire E Stelly1,2,3, Xin Fu2,4
1Department of Psychology, Tulane University, New Orleans, LA, USA.
Nature
|January 17, 2024
まとめ
研究者らは 凍結や逃走などの 防御行動を制御する 新しい脳の経路を発見しました 中枢桃体 (CeA) へのドーサル・ペドゥンキュラー (DP) 回路は,高強度な脅威に対する反応と回避に不可欠です.
科学分野:
- 神経科学
- 行動生物学
- 前頭皮質の研究
背景:
- 適切な脅威対応は 生き残るために不可欠です
- 制御不能な防御反応は PTSDやパニック障害などの 精神疾患と関連しています
- 中枢桃体 (CeA) の神経回路は脅威の行動を制御しますが,高強度反応のためのCeA興奮の源は不明でした.
研究 の 目的:
- ニューロンの刺激源を特定する
- 前頭前皮質から背中前皮質への未知の投影を特徴づける.
- 防御行動における この経路の役割を解明するためです
主な方法:
- 神経解剖学的マッピング
- イン・ビボカルシウムイメージング
- 機能的な操作
- 電気生理学
- 凍結と飛行の行動パラダイム
主要な成果:
- DP前頭皮質から中央のCeAへの新しいグルタマタージック投影が特定されました.
- DP-to-CeAニューロンは 状況に応じて 高強度な脅威によって活性化されます
- DPからCeAへの経路は,回避とフライトの行動に必要かつ十分である.
- 脳の中枢部に発射する 中央部に発射する 中央部に発射する 中央部に発射する
結論:
- 防御反応を制御する 非正規の上から下への経路が DP 皮質から CeA にあります
- この経路は 避けて逃げるのに 重要な役割を果たします
- この回路を理解することで 脅威と恐怖の反応の 神経生物学について 新たな洞察が得られます
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