最近 の 減量 後 の 癌 の 診断
Qiao-Li Wang1,2, Ana Babic1, Michael H Rosenthal3,4
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, Massachusetts.
JAMA
|January 23, 2024
まとめ
医療従事者の原因不明の体重減少は 次の1年以内に癌を発症するリスクが高いと関連しています この関連性は,上部胃腸癌において特に強く見られます.
科学分野:
- 腫瘍学
- 流行病学
- 予防 医療
背景:
- 原因不明の体重減少は一般的な臨床観察である.
- 最近の体重減少と後の癌のリスクとの関連は不明である.
研究 の 目的:
- 体重を減らす医療従事者の癌診断率を調査する.
- 最近減量した人と減量していない人の癌発生率を比較する.
主な方法:
- 看護師の健康調査と医療従事者のフォローアップ調査の予測コホート分析
- 体重の変化は2年ごとに評価され,意図性は食事と身体活動に基づいて分類される.
- 癌の診断は,体重変化の後の12ヶ月間,長期のフォローアップで追跡された.
主要な成果:
- 体重が10%以上減少した参加者は,がんの発生率が (869/100,000人/年) 減少していない参加者よりも著しく高かった.
- 低意図的体重減少の症例では,対照群 (1220/100,000人/年) と比較して,癌のリスクが著しく高かった.
- 上部胃腸がんは,体重減少グループ (173/100,000人/年) で,対照グループ (36/100,000人/年) よりも顕著でした.
結論:
- 医療従事者の最近の体重減少は,癌のリスクが著しく増加している.
- 上部胃腸がんは,最近体重が減った人の間で不均衡に表れています.
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