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Updated: Jul 5, 2025

Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors
09:11

Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors

Published on: November 23, 2019

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ウリジンビスホスフォネート 差別化フォスホグリコシル移転酵素スーパーファミリー

Leah M Seebald1, Pouya Haratipour2, Michaela R Jacobs2

  • 1Department of Biology and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Journal of the American Chemical Society
|January 25, 2024
PubMed
まとめ

研究者らは,バクテリアのグリココンジュゲート合成に関与するフォスフォグリコシルトランスファーゼ (PGTs) を阻害する新しい尿素二酸化塩素 (UBPs) を開発した. これらのUBPは,異なるPGTスーパーファミリーに対する明確な結合メカニズムを明らかにし,プロカリオット酵素を標的とした新しい抗生物質の開発の可能性を提供しました.

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