関連する実験動画

Updated: Jul 4, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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Ca2+感受受容体のアロステリック調節とGタンパク質選択性

Feng He1, Cheng-Guo Wu1, Yang Gao1,2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|February 7, 2024
PubMed
まとめ

カルシウム感受受体 (CaSR) の構造は,Gタンパク質を活性化させ,シナカルセトのような薬に反応する方法を明らかにします. ポリアミンとL-トリプトファンはまた,異なるメカニズムを通じてCaSRの活性を調節する.

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