食物アレルギーと食物関連アナフィラキシーの管理
Edward G A Iglesia1, Mildred Kwan2, Yamini V Virkud3
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
JAMA
|February 13, 2024
まとめ
アメリカではIgE媒介の食物アレルギーが多く 何百万人も罹患しています 赤肉に対する重度のアレルギー反応の原因が増加しており,注意深く避け,迅速にエピネフリン治療を行う必要があります.
科学分野:
- アレルギーと免疫学
- 公衆衛生
- 流行病学
背景:
- IgE媒介の食物アレルギーは アメリカで何百万人も患っており ピーナッツや木の実や貝殻などの特定の食品が 深刻な反応を引き起こしています
- アルファガール症候群は,哺乳類の肉 (アルファガール) に対するIgE媒介性アレルギーであり,かなりの集団に影響を与え,成人における食物関連のアナフィラキシーの主要な原因である.
研究 の 目的:
- 米国におけるIgE媒介性食物アレルギーの流行,原因,管理についてまとめます.
- アルファガール症候群は 食物関連のアナフィラキシーの 重要な原因であり,増加しています.
主な方法:
- 米国における食物アレルギーに関する疫学データのレビュー
- アルファガール症候群の有病率と臨床的意義の分析
- 食品アレルギーとアルファガール症候群の現在の管理戦略の要約
主要な成果:
- 一般的な食物アレルゲンは,貝殻,乳製品,ピーナッツ,木の実,魚,卵,小麦,大豆,芝生などです.
- アルファガール症候群は,米国で96,000~450,000人の個人に影響し,一部の地域では血清流行率が31%まで上昇しています.
- 食に関連したアナフィラキシは死亡率が低い (年当たり0.04%) が,直ちにエピネフリン治療が必要である.
結論:
- IgE媒介の食物アレルギーとアルファガール症候群は一般的であり,生命を脅かすアナフィラキシーを引き起こす可能性があります.
- 管理は,アレルゲン (アルファガール症候群の食物との噛み) を回避し,エピネフリンを迅速に投与することに焦点を当てています.
- 新興の免疫療法は ピーナッツアレルギーのような 特定の食物アレルギーの 新しい治療法を提供します
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