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関連する概念動画

The Replisome03:01

The Replisome

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA Packaging00:58

DNA Packaging

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Overview
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The DNA Replication Fork01:02

The DNA Replication Fork

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An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
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Updated: Jul 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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スパイサー プログラム された 二次元 DNA オリガミ アセンブリ

Yongjun Liu1, Zheze Dai1, Xiaodong Xie1

  • 1School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|February 14, 2024
PubMed
まとめ
この要約は機械生成です。

DNAスペーサーの長さをプログラムすることで 精密にDNAオリガミの組み立てを制御できます この方法はハイブリッド化の効率とパターンの多様性を高め,複雑なナノ構造の高収量を実現します.

さらに関連する動画

Designing a Bio-responsive Robot from DNA Origami
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Designing a Bio-responsive Robot from DNA Origami

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Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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関連する実験動画

Last Updated: Jul 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

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Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

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Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

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科学分野:

  • ナノテクノロジー
  • 生物分子工学
  • 材料科学

背景:

  • 二次元 (2D) DNA オリガミの組み立ては,高度な2D素材を作成するための重要な方法です.
  • DNAスペーサーは,ハイブリッド化による2DDNAオリガミアセンブリにおける重要なコネクタであり,ユニット結合に影響を与えます.

研究 の 目的:

  • 2D DNA オリガミ配列の組み立てと粘着端のハイブリッド化にどのように影響を与えるかを調査する.
  • DNA オリガミナノ構造の組み立て効率とパターンの多様性を最適化します

主な方法:

  • ハイブリッド化の効率を分析するために DNA-PAINT 超高解像度画像を用いた.
  • 分子ダイナミクスのシミュレーションを使用して,スペーサーの長さと熱力学的変動の相関を研究した.
  • DNAオリガミの結合半径を制御する プログラムされたDNAスペーサーの長さ

主要な成果:

  • スパイサーの長さは,正方形のDNAオリガミ (SDO) ユニットアセンブリにおける粘着端のハイブリッド化効率に大きく影響する.
  • 組み立ての効率とパターンの多様性は,プログラムされたスペーサー長さに非常に依存しています.
  • SDOトリマーとテトラマー組立では,スペーサープログラム戦略を用いて高収量 (∼98%) を達成した.

結論:

  • 2D DNA オリガミの組み立てを正確に制御するための重要なパラメータです.
  • この戦略により,高効率で多様で複雑なDNAナノ構造が作られます.
  • 発見はDNAナノ構造の 精密アセンブリを前進させ 将来の応用に役立てます