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Updated: Jul 3, 2025

Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells
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Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells

Published on: June 19, 2018

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人間の誘発性多能幹細胞から心臓弁細胞への誘導的差別化

Ziwen Cai1,2, Miaomiao Zhu2,3, Li Xu1

  • 1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (Z.C., L.X., Y.X., W.Y.Y., H.C., R.G., X.Q, J.S., W.Q., N.D.).

Circulation
|February 15, 2024
PubMed
まとめ

研究者は,機能的なヒト誘発性多能幹細胞 (hiPSCs) を生成する効率的なプロトコルを開発しました. この突破は,研究のための弁細胞の信頼性の高い源を提供することで,弁疾患の研究における重要な課題に取り組んでいます.

キーワード:
細胞の分化内皮細胞心臓弁誘導された多能幹細胞単細胞遺伝子発現分析

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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