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関連する概念動画

Nuclear Transmutation03:20

Nuclear Transmutation

17.5K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
17.5K
Subatomic Particles03:37

Subatomic Particles

92.3K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
92.3K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

8.6K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
8.6K
Types of Radioactivity03:23

Types of Radioactivity

16.8K
The most common types of radioactivity are α decay, β decay, γ decay, neutron emission, and electron capture.
Alpha (α) decay is the emission of an α particle from the nucleus. For example, polonium-210 undergoes α decay:
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Proton (¹H) NMR: Chemical Shift01:07

Proton (¹H) NMR: Chemical Shift

1.7K
Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei...
1.7K
Nuclear Stability03:18

Nuclear Stability

18.8K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
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関連する実験動画

Updated: Jul 3, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

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プロトンは新しいファーストレスポンダーです

Bingxu Liu1

  • 1Institute for Protein Design, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|February 15, 2024
PubMed
まとめ

ヒトのSTINGタンパク質は 経路として機能し 免疫システムとその複雑な防御メカニズムに関する 知識を大幅に向上させています

科学分野:

  • 免疫学
  • 分子生物学
  • 細胞生物学

背景:

  • STING (インターフェロン遺伝子の刺激剤) は,先天的な免疫における重要なタンパク質です.
  • 循環性ダイヌクレオチドを感知し,免疫反応を開始する役割はよく確立されています.
  • しかし 信号伝達以外の 正確な分子機能は 謎のままです

研究 の 目的:

  • ヒトのSTINGの構造と機能を 調べるためだ
  • STINGが免疫信号伝達における 正規の役割を超えた機能を持っているかどうかを判断する.
  • 新しく発見されたSTINGの機能の 基礎にある分子メカニズムを解明する

主な方法:

  • ヒトSTINGの高解像度構造を決定するためにX線結晶学を用いた.
  • STINGのイオンチャネル活動を評価するために生化学的測定が行われました.
  • 免疫反応におけるSTINGチャネル機能の生理学的関連性を評価するために,細胞ベースの測定法を使用した.

主要な成果:

  • 人間のSTINGは 細胞膜に 機能的なイオンチャネルを形成していることが判明しました
  • このチャネル活動は,STINGの活性化状態と周期性ダイヌクレオチドとの相互作用によって制御されます.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

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Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation
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  • STINGチャネル機能は,免疫シグナル分子の効率的な転位に不可欠であることが示されました.
  • 結論:

    • STINGのイオンチャネル機能の発見は 生まれつきの免疫を理解する上で パラダイムシフトを表しています
    • この発見は,STING媒介の免疫経路を標的とした治療の新たな道を開きます.
    • 信号ハブとチャネルとしてのSTINGの二重役割は,ホスト防衛への複雑で多面的な貢献を強調しています.