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Updated: Jul 3, 2025

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UDPG経由でS1Pを阻害することで,肝臓の糖分生成が逆行する

Jie Chen1, Yabo Zhou1, Zhuohang Liu1

  • 1Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

Science (New York, N.Y.)
|February 15, 2024
PubMed
まとめ

この研究では,尿素二酸化グルコース (UDPG) が肝細胞の脂肪の蓄積を防止し,代わりにグリコゲンの貯蔵を促進する方法を明らかにしました. UDPGの投与は,マウスモデルで非アルコール性脂肪肝 (NAFLD) を効果的に治療しました.

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