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Updated: Jul 2, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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メタラフォトレドックスデオキシジフローロメチル化による直接のバイオイスステル置換

Edna Mao1, Cesar N Prieto Kullmer1, Holt A Sakai1

  • 1Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.

Journal of the American Chemical Society
|February 16, 2024
PubMed
まとめ

薬剤化学者は 薬の発見の遅い段階で アルコールを二酸化メチル基に変換できます この新しい方法は,長い合成を避け,薬剤候補の評価とADMEの特性を改善します.

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