Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.0K
Determination01:51

Determination

18.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Bacillus Calmette-Guérin (BCG) immunotherapy reprograms CNS immunity and alters Alzheimer's biomarkers: results from two open-label clinical trials.

Communications medicine·2026
Same author

IAPEz retrotransposons regulate the first lineage segregation in mouse pre-implantation development.

Nucleic acids research·2026
Same author

The Wnt inhibitor Tiki2 maintains articular cartilage homeostasis and protects against osteoarthritis.

Science signaling·2026
Same author

Developmental chronology of mouse embryo from 2-cell stage through birth.

Nature cell biology·2026
Same author

Population-Based Study of Drug-Resistant Epilepsy Before Age Two: Predominance of Developmental and Epileptic Encephalopathies.

Neurology international·2026
Same author

Exploring the somatic mutational landscape of ovarian cancer in Estonia.

Acta oncologica (Stockholm, Sweden)·2026

関連する実験動画

Updated: Jul 2, 2025

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

17.1K

発達中のKDM5CによるWNT信号制御は認知に影響する

Violetta Karwacki-Neisius1, Ahram Jang2,3, Engin Cukuroglu4

  • 1Division of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. violetta.karwacki-neisius@childrens.harvard.edu.

Nature
|February 21, 2024
PubMed
まとめ

KDM5C遺伝子の変異は 神経発達のタイミングを乱すことで 知的障害を引き起こします 発達中のWNT信号を一時的に復元すると 細胞の変化を修正し 認知の欠陥を救えるのです

さらに関連する動画

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.6K
A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.1K

関連する実験動画

Last Updated: Jul 2, 2025

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

17.1K
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.6K
A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.1K

科学分野:

  • 神経科学
  • 遺伝学
  • 発達生物学

背景:

  • KDM5C変異はX関連知的障害ではよく見られるが,その背後にあるメカニズムは不明である.
  • KDM5Cの役割を理解することは 認知障害の治療に不可欠です

研究 の 目的:

  • 神経発達におけるKDM5Cの機能と知的障害との関連を解明する.
  • KDM5C変異が認知障害につながる分子メカニズムを調査する.

主な方法:

  • 患者の誘発性多能性幹細胞とKdm5cノックアウトマウスモデルを使用した.
  • 細胞,染色体,染色体,そして行動分析を行った.
  • WNT信号経路の調節の役割を調査した.

主要な成果:

  • 神経発達タイミングの重要なレギュレータとして KDM5Cを特定しました
  • 特定の開発ウィンドウでKDM5CのWNT出力を直接制御することを実証した.
  • 暫定的なWNT経路調節がKDM5C障害に関連した細胞および行動的欠陥を救済することを示した.

結論:

  • KDM5Cは 適切な神経発達のタイミングを 守る役割を果たし その障害が知的障害を引き起こすのです
  • 暫定的なWNT信号調節は,KDM5Cに関連した知的障害に対する潜在的な治療戦略を提供します.
  • 記憶や不安といった 長期にわたる認知機能に影響する WNT信号の 暫定的な性質を明らかにしました