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Updated: Jul 2, 2025

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分子内二価接着剤による標的型タンパク質分解

Oliver Hsia1, Matthias Hinterndorfer2, Angus D Cowan1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.

Nature
|February 21, 2024
PubMed
まとめ

内分子双価粘着剤 (IBG) は,新しい標的型タンパク質分解戦略を表しています. これらの化合物は,cisの標的タンパク質ドメインを誘導し,E3リガース結合を強化し,ユビキチネーションを促進します.

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