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Updated: Jul 2, 2025

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
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UFM1 E3リガゼは,ERトランスロコンから60Sリボソームを認識して放出する

Linda Makhlouf1, Joshua J Peter2, Helge M Magnussen2

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|February 21, 2024
PubMed
まとめ

UFM1リボソームE3リガゼ (UREL) 複合体は,停止したリボソームを修正し,ER膜から放出を促進します. このUFMylationプロセスは,タンパク質ホメオスタシスに不可欠であり,リボソームをSEC61トランスロコンから分離することによってリサイクルします.

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