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Updated: Jul 2, 2025

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

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微分エノイル還元酵素による抗生物質の骨格多様化とトランス-アシルトランスファーゼポリケチド合成酵素におけるモジュールイテレーション

Xinyun Jian1,2,3,4, Fang Pang1, Christian Hobson1

  • 1Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

Journal of the American Chemical Society
|February 23, 2024
PubMed
まとめ

グラディオリンとエタンギエン抗生物質の生物合成を調査することで,ポリケチド合成酵素 (PKS) の微妙な違いが構造的多様性を生み出すことが明らかになった. この研究は 微生物の自然産物進化と 工学的な可能性に光を当てています

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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü602809:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Antibiotic Selection00:57

Antibiotic Selection

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tRNA Activation02:26

tRNA Activation

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Protein Modifications in the RER

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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