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Updated: Jul 2, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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抗TIGIT抗体は,骨髄細胞とTreg細胞によるPD-L1阻害を改善する

Xiangnan Guan1, Ruozhen Hu1, Yoonha Choi1

  • 1Genentech Inc., South San Francisco, CA, USA.

Nature
|February 28, 2024
PubMed
まとめ

チラゴルマブとアテゾリズマブの併用は,免疫細胞を活性化することで,がんのアウトカムを改善します. この免疫療法の組み合わせはマクロファージとT細胞の反応を強化し,TIGIT阻害剤の新たなメカニズムを示唆しています.

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Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood06:07

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity06:16

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

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関連する概念動画

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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