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関連する概念動画

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)01:20

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

1.0K
Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...
1.0K
Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)01:22

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

1.1K
Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the...
1.1K
Spin–Spin Coupling: One-Bond Coupling01:17

Spin–Spin Coupling: One-Bond Coupling

969
Coupling interactions are strongest between NMR-active nuclei bonded to each other, where spin information can be transmitted directly through the pair of bonding electrons. While nuclei polarize their electrons to the opposite spins, the bonding electron pair has opposite spins. Configurations with antiparallel nuclear spins are expected to be lower in energy. When coupling makes antiparallel states more favorable, J is considered to have a positive value. The one-bond coupling constant, 1J,...
969
¹H NMR: Long-Range Coupling01:27

¹H NMR: Long-Range Coupling

1.7K
The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...
1.7K
Spin–Spin Coupling Constant: Overview01:08

Spin–Spin Coupling Constant: Overview

921
In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must...
921
Mutual Inductance01:24

Mutual Inductance

2.3K
Inductance is the property of a device that tells us how effectively it induces an emf in another device. In other words, it is a physical quantity that expresses the effectiveness of a given device.
When two circuits carrying time-varying currents are close to one another, the magnetic flux through each circuit varies because of the changing current in the other circuit. Consequently, an emf is induced in each circuit by the changing current in the other. Therefore, this type of emf is called...
2.3K

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関連する実験動画

Updated: Jul 2, 2025

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

13.5K

アミナティブ・スズキ・ミヤウラ・カップリング

Polpum Onnuch1, Kranthikumar Ramagonolla1, Richard Y Liu1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Science (New York, N.Y.)
|February 29, 2024
PubMed
まとめ
この要約は機械生成です。

この研究は,スズキ-ミヤウラ結合にニトロンの挿入を統合し,C-C結合形成をダイアリルアミンのC-N結合形成に変換する. この新しいアプローチは,より広範な合成アプリケーションのためのスズキ-ミヤウラとブックウォルド-ハートウィッグの結合経路を統合します.

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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

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関連する実験動画

Last Updated: Jul 2, 2025

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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科学分野:

  • 有機化学
  • カタリシス
  • 合成方法論

背景:

  • スズキ・ミヤウラ結合はC−C結合を形成し,バッハウォルド・ハートウィッグ結合はC−N結合を形成する.
  • 既存の方法では,C-CとC-N結合形成にはしばしば異なる出発材料が必要です.

研究 の 目的:

  • Suzuki-MiyauraとBuchwald-Hartwigの結合経路を統合する新しい反応を開発する.
  • 統一された触媒処理で一般的な原料からダイアリルアミンを生成する.

主な方法:

  • スズキ・ミヤウラ反応に正式な窒素挿入プロセスを組み込む.
  • パラジウム触媒と 厚なフォスフィンリガンドを使用した
  • 商用アミネーション用反応剤を使用した.

主要な成果:

  • バイアリルからC-N-C結合ダイアリルアミンに 鈴木・ミヤウラ製品を成功裏に改造しました
  • 様々なアリルハリド,偽ハリド,ボロン酸,エステルで効率的な反応性を達成した.
  • 多様な機能群とヘテロサイクルとの互換性が実証されている.

結論:

  • 開発された方法は,スズキ・ミヤウラとブッチャウォルド・ハートウィッグのカップリング戦略に効果的に合致します.
  • 機械学的研究は,結合形成の順序の柔軟性を明らかにし,広範な適用可能性を示唆した.
  • 新しい核愛性,電愛性,多成分反応への拡張の可能性が特定された.