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Updated: Jul 1, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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Published on: April 16, 2021

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ラジカルSAM酵素 PylBは,SAMをコファクターとして使用して,ピロリシンのバイオシンセシスにおけるリシルラジカル中間物質を生成する

Baixu Ma1, R David Britt2, Lizhi Tao1

  • 1Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.

Journal of the American Chemical Society
|March 1, 2024
PubMed
まとめ

研究者らは,ピロリシン (22番目のアミノ酸) の生物合成における重要な酵素であるPylBのメカニズムを解明した. 彼らは,S-アデノシル-l-メチオニン (SAM) が触媒的コファクタとして作用し,この重要な骨髄経路におけるリジル中間物質を明らかにした.

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