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Updated: Jul 1, 2025

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
11:25

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Published on: March 18, 2017

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G4-リガンド結合オリゴヌクレオチドは,個々のG4DNA構造の選択的結合と安定化を媒介する

Andreas Berner1, Rabindra Nath Das2, Naresh Bhuma2

  • 1Department of Medical Biochemistry and Biophysics, Umeå University, Umeå 901 87, Sweden.

Journal of the American Chemical Society
|March 2, 2024
PubMed
まとめ

研究者は,ガイドオリゴヌクレオチドに結合したG4リガンドを使用して,個別のG四重複 (G4) DNA構造を特異的に標的とする新しい方法を開発した. この戦略は,G4DNAの選択性の課題を克服し,研究と潜在的な治療のための新しいツールを提供します.

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