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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

184
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
184
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

163
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
163
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

137
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
137
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
118

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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クローン病

Michael Dolinger1, Joana Torres2, Severine Vermeire3

  • 1Division of Paediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Lancet (London, England)
|March 4, 2024
PubMed
まとめ

クローン病は慢性的な胃腸炎症です 現在の管理は寛解を超えたより深い治癒目標に焦点を当てており,患者の改善のために先進的な治療法を使用しています.

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科学分野:

  • 胃腸内科
  • 免疫学
  • 内科 医学

背景:

  • クローン病は慢性的な炎症性胃腸疾患で,潜在的に進行的な腸損傷を引き起こす可能性があります.
  • 遺伝的に感受性の高い個体における免疫系不調を伴う多因性の病因性である.
  • 炎症は典型的には不連続で,断片的であり,トランスムラルで,しばしば大腸と大腸に影響します.

研究 の 目的:

  • クローン病の現在の診断基準を概説します
  • より深い治癒目標を目指す治療戦略の進化を記述する.
  • クローン病の治療の 進歩を強調するためです

主な方法:

  • 診断はイレオコロノスコピーと ヒストロジーによるもので,検査やイメージング,心理社会的評価も含まれます.
  • 治療戦略には現在,内視鏡治療,組織学,および経口標的が含まれています.
  • 先進的な治療法と新しい経路が開発され,利用されています.

主要な成果:

  • 診断評価は包括的で,臨床,検査,イメージング,心理社会的データを統合しています.
  • 治療の目標は より深い寛解を達成し 疾患の進行を遅らせることに変わりました
  • 新しい治療法により 安全性が向上し 治療の新たな時代が始まりました

結論:

  • クローン病の治療は 総合的な評価と 深い癒しに焦点を当てて進んでいます
  • 早期に有効な先進的な治療法と 新しい治療法により 治療結果が改善されています
  • 将来の戦略は,治療法,食事,改善されたモニタリングツールを組み合わせて,患者のケアを向上させるかもしれません.