発声の脳幹制御と呼吸との調整
Jaehong Park1,2, Seonmi Choi1, Jun Takatoh1
1Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
まとめ
研究者らは,声帯の閉塞とマウスの超音波発声 (USV) を制御する,声帯特異性ニューロン (RAmVOC) を特定した. これらのRAmVOCニューロンは 呼声と呼吸を調整し 呼声帯の閉塞にインスピレーションが優先します
科学分野:
- 神経科学
- ボカライゼーション研究
- 呼吸器のコントロール
背景:
- 喉の筋肉の精密な制御が呼吸と連携する必要があります.
- 声 - 喉頭 - 呼吸器の調整のための神経機構は完全に理解されていません.
研究 の 目的:
- ネズミの声帯誘導と超音波発声 (USV) を制御する神経回路を特定する.
- 声の生成と呼吸の調整における反曖昧な核 (RAmVOC) ニューロンの役割を調査する.
主な方法:
- ネズミの反曖昧な核 (RAmVOC) にある発声特有の前運動神経細胞の識別.
- RAmVOCニューロン活動と阻害シナプスの実験操作.
- 発声パターンと呼吸相調整の分析
主要な成果:
- RAmVOCニューロンは,声帯の閉塞とUSVの生成に必要で十分である.
- RAmVOCの活性化期間は,USVの音節長さと有効期限に影響する.
- インスピレーション中のRAmVOCのゲートからの阻害的な入力により,声と呼吸の協調性が確保されます.
結論:
- 逆曖昧な核は発声に不可欠な刺激性前運動ニューロンを含んでいます
- RAmVOCとその抑制インプットを含む神経回路が声と呼吸の調整を制御する.
- 阻害ゲーティングの障害は 発声と呼吸の間の失調につながります
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