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関連する概念動画

Menopause01:28

Menopause

158
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
158
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

369
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
369
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

496
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
496
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Hormonal Regulation01:40

Hormonal Regulation

43.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.5K
Infertility in Females01:28

Infertility in Females

292
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
292

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関連する実験動画

Updated: Jul 1, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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早期 閉経 の 後 の 健康 の 改善

Gita D Mishra1, Melanie C Davies2, Sarah Hillman3

  • 1Australian Women and Girls' Health Research Centre, School of Public Health, University of Queensland, Brisbane, QLD, Australia.

Lancet (London, England)
|March 8, 2024
PubMed
まとめ

早期の閉経は40歳から44歳までに起こり 慢性疾患のリスクが高くなり よりよい臨床的指導が必要です 早期 閉経 を スペクトル と 見る こと は,女性 の 診断 と 治療 を 改善 する

さらに関連する動画

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

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関連する実験動画

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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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科学分野:

  • 生殖内分泌学
  • 女性 の 健康
  • 臨床医学

背景:

  • 閉経は通常50~51歳の頃に起こります
  • 早期の更年期 (40歳~44歳) は,世界全体の8~12%の女性に影響します.
  • 早期の卵巣不全 (40歳未満) は,さらに2〜4%の女性に影響します.

研究 の 目的:

  • 早期更年期と早発性卵巣不全に関連する健康リスクを強調する.
  • 早期更年期における臨床ガイドラインのギャップを埋めること.
  • 早期更年期管理のためのスペクトルベースのアプローチを提案する.

主な方法:

  • 早期閉経の短期的および長期的影響に関する証拠のレビュー
  • 臨床診断と管理のための実用的な枠組みの開発
  • 患者 の 症状,年齢,病歴,優先 順位 を 考慮 する.

主要な成果:

  • 早期の更年期と早発性卵巣不全は,骨粗鬆症や心血管疾患のリスクの増加と関連しています.
  • 早期 閉経 を 経験 し て いる 女性 は,心理 的 な 苦悩 に 直面 し,支援 を 受け ない よう に 感じる か も しれ ませ ん.
  • 既存のガイドラインは主に早発性卵巣不全に対処し,早期更年期にギャップを残しています.

結論:

  • 早期 更年期 は 厳格 な 年齢 制限 に よっ て 考える べき で は ない.
  • 生活の質と健康状態を最適化するために 個別化された管理の枠組みが提案されています
  • 早期更年期における現在の証拠のギャップを補うためにさらなる研究が推奨されています.